Advances and challenges in phenylketonuria

Phenylketonuria: nutritional advances and challenges

Despite the appearance of new treatment, dietary approach remains the mainstay of PKU therapy. The nutritional management has become complex to optimize PKU patients' growth, development and diet compliance. This paper review critically new advances and challenges that have recently focused attention on potential relevant of LCPUFA supplementation, progress in protein substitutes and new protei...

Advances and challenges in recombinant protein expression in Escherichia coli

Monoclonal Antibodies as Therapeutic Agents: Advances and Challenges

Despite the major advances in conventional forms of treatment (i.e. surgical techniques, radiotherapy and chemotherapy) and improved survival rates, cancer is still the second leading cause of death in developing countries. One major limitation of cytotoxic drugs and radiation in the treatment of cancer patients is their inability to discriminate between malignant and normal tissues. This in tu...

Challenges to breastfeeding infants with phenylketonuria.

Breastfeeding duration for infants with phenylketonuria (PKU) is less than other full-term infants. However, no study has examined the challenges encountered by mothers' breastfeeding infants with PKU. In 75 mothers of a child with PKU, three categories of breastfeeding challenges were identified: common breastfeeding issues, breastfeeding and PKU, and no challenges. The common breastfeeding is...

Nutrition and inborn errors of metabolism: challenges in Phenylketonuria

Phenylketonuria (PKU) is caused by the deficiency of the phenylalanine hydroxylase enzyme, which converts phenylalanine (Phe) to tyrosine. If left untreated from birth, this deficiency results in high levels of Phe in the blood, neurotoxic to the brain [1].The restriction of dietary Phe represents the mainstain of PKU management. PKU diet is mainly made up by variable amounts of vegetables and ...